Summary

A motivated, responsible professional with 13 years experience in spectroscopy research and development. Solid experience in a broad range of spectroscopic and spectral imaging hardware development, in-vivo spectroscopy and data analysis, statistics, and management. Strong analytical, organizational, and leadership skills. Excellent oral and written communication, presentation, and computer skills.

Spectroscopic Data Analysis

· Performed all aspects of the data analysis for large statistically relevant hyperspectral imaging studies in medicine, on both human and animal experimental models, including summarizing spectroscopic results for acceptance into medical journals.

· Key scientist in a large team of scientists researching the methodologies necessary for the development of a practical non-invasive glucose monitor for home consumer use. This involved the design and analysis of virtually all of the clinical (human) and animal studies during the R&D cycle.

· Excellent background, theoretical understanding and practical skills in chemometrics and multivariate analyses, particularly as applied to spectroscopic data. Utilized numerous supervised classification (LDA, QDA, nearest neighbor searches), unsupervised classification (hard and fuzzy clustering, hierarchical clustering, ANOVA based methods), and quantitative regression (MLR, PLS, ridge regression) methods in the analysis of spectra and am well versed in the strengths and weaknesses of spectral preprocessing methodologies (normalization, smoothing, deconvolution, PCA).

· Thorough understanding of the requirements to ensuring robust results from the analysis of in-vivo spectroscopic data, including practical experimental design considerations as well as mathematical limitations and utilities.

Spectroscopy and Spectroscopic Imaging

· Designed, developed and implemented practical and inexpensive liquid crystal tunable filter (LCTF) based spectroscopic imaging systems for macroscopic samples and pioneered data analysis methods for their application in medicine.

· Have practical experience with and a thorough understanding of IR, NIR, UV/Vis, fluorescence, Raman and NMR spectroscopy and their applications, particularly as with respect to their in-vivo uses. Responsible for maintenance, repair, upgrading and optimization and troubleshooting of a wide range of spectrometers at IBD.

· Thoroughly familiar with the theoretical and practical functioning of both step-scan FT-IR and LCTF based array detector systems for spectroscopic imaging as well as with their application and methods for data analysis.

· Both led and worked closely with the engineering department at Argose during the development of all research-grade spectrometers as well as prototype instrumentation, providing key input on analytical methodologies, spectroscopic trade-offs and data handling issues necessary to optimize the ability to measure glucose.

In-Vivo Spectroscopy

· Performed leading research in several areas in the application of spectral imaging to medical disease diagnosis, including the early detection of peripheral vascular disease, in the non-subjective determination of shock, and in the early prediction of skin flap failure in plastic surgery.

· A part of a team working on the non-invasive monitoring and diagnosis of rheumatoid arthritis using near infrared and visible spectroscopy. This work led to US patent #6,424,859, which is owned by the National Research Council of Canada but is still not licensed to anyone.

· Three years working on non-invasive measurements of skin UV/Vis diffuse reflectance and fluorescence properties, including spatial, spectral and temporal heterogeneities and the impact of various physiological and phenotypic effects on spectral properties.

· Worked on a two-year, 195 case study working towards developing a screening method for basal cell carcinoma and other skin lesions, which showed the potential of the methodology.

· Excellent knowledge of in-vivo skin spectral properties and chromophores/fluorophores in the UV, visible and near infrared.

Analytical Chemistry

· Worked for two years as an analytical chemist performing identification analyses of drugs of abuse for courtroom testimony. This included all of the analysis, calibration, SOPs and other documentation necessary for presentation before the court.

· Very familiar with many analytical instrumentation techniques, including HPLC, GC, GC-MS, FT-IR and NMR. This includes a solid theoretical understanding of the methods as well as many years of practical experience with various applications such as structural identification by NMR, IR and MS, quantitative analyses by GC and HPLC and screening of mixtures for impurities by GC and GC-MS.

Management & Leadership

· Responsible for all aspects of the research and development of an eight member Analysis Group at Argose, whose function is to design protocols and analysis methods for the data from human and animal experiments aimed at developing and improving the ability to measure glucose non-invasively using the Argose methodology.

· Was solely responsible for the proposal, design, implementation and reporting of an extensive contract between the National Research Council of Canada and Unilever Research to investigate the utility of using LCTF-based spectroscopic imaging systems to monitor facial regreasing without contacting the skin.

· The fifth employee at Argose and its first spectroscopist. Responsible for the management, development, hiring, and growth as well as the research of the Analysis Group, which grew to a nine-person group, including five direct reports.

· A member of the senior management team at Argose, responsible for developing and working to meet timelines, research plans, budgets, and also to provide the majority of the scientific data that was required in support of fund raising efforts.

· Managed the development of and assisted in the programming of the software packages, which are used for the vast majority of the data collection, archiving, databasing and analysis at Argose, using concurrent programming methods.

Experience

Cambridge Research and Instrumentation

Senior Spectral Imaging Scientist (2003 – present)

HyperMed, Inc.

Chief Technical Officer (2002 – 2003)

Argose, Inc.

Director of Analysis (1999 – 2002)

Institute for Biodiagnostics, National Research Council of Canada

Technical Officer (1992 – 1999)

Health Protection Branch, Health and Welfare Canada

Analytical Chemist (1990 – 1992)

University of Manitoba (part time)

Research Assistant, Chemistry (1988 – 1992)

Education

University of Manitoba, M.Sc., Chemistry (1990)

University of Winnipeg, B.Sc., Chemistry (1988)

General

· Proficiency in MS Windows, MS Office, Linux, Matlab, LabView, HTML, CorelDraw.

· Developed an award-winning website during the early days of the WWW (pre-1997).

· 2 issued patents and 9 Patents Pending

· 31 publications, 14 conference presentations