Mario Vassalle

Curriculum Vitae
Home
About Me
The Periodic Corner
Contact Me
Curriculum Vitae

mario.vassalle@downstate.edu

MARIO VASSALLE

 

PERSONAL

 

Born:                           Viareggio, Lucca, Italy.

Married:                      Anna Maria

Children:                     Andrew G.     

                                    Alessandra A.

Massimo B.

Roberto M.

Francesca A.

 

 

EDUCATION:  

 

Undergraduate:

Liceo‑Ginnasio G. Carducci, Viareggio, B.A. 1947

 

             Graduate:

University of Pisa, Medical School, M.D. cum Laude, 1953

University of Pisa, Medical School, Specialization in Cardiology cum Laude, 1955.

 

 

TRAINING AND TEACHING EXPERIENCE

 

Medical Internship, Istituto di Medicine and Cardiology, University of Pisa Medical School, 1953‑1955.

 

Assistant, Istituto di Patologia Medica, University of Pisa Medical School, 1956‑1958.

 

Acting Chief Resident in Medicine, French Hospital, New York City, 1958‑1959.

 

Trainee, Cardiovascular Research and Training Program, Department of Physiology, Medical College of Georgia, Augusta, Ga., 1959‑1960 (Dr. W.F. Hamilton).

 

Postdoctoral Fellow, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY 1960‑1961. (Dr. B. F. Hoffman).

 

New York Heart Association Fellow, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY, 1961‑1962 (Dr. B. F. Hoffman).

 

Instructor, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY, March‑Sept., 1962.

 

N.I.H. Fellow, Physiologisches Institut, University of Bern, Bern, Switzerland, 1962‑1964 (Dr. S. Weidmann).

 

Visiting Assistant Professor, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY, 1964‑1965.

 

Assistant Professor, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, NY, 1965‑1966.

 

Associate Professor, Department of Physiology, State University of New York, Downstate

Medical Center, Brooklyn, NY, 1966‑1971.

 

Professor, Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, 1971‑2006.

 

Professor Emeritus, Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, NY, 2006-.

 

 

VISITING PROFESSOR

 

Department of General Physiology, University of Ferrara, Italy, January‑August 1971.

 

Department of Physiology and Biophysics, University of Vermont, Burlington, Vermont, January‑July 1978.

 

Department of Medicine, Catholic University Gemelli, Rome, Italy, October 1984‑April 1985.

 

National Defense Medical Center, Taipei, Taiwan, November-December 1983, December1987, June 1991, November 1992, October 1995, November 1997, November 2000, November 2003.

 

Instituto Nacional de Cardiologia, Mexico D.F., Mexico, Sept. 1988, Jan. 1989, March 1990, Nov.-Dec. 1991, May-June 1993.

 

Department of Physiology and Biophysics, State University of New York, Stony Brook, NY, January-July, 1994.

 

AWARDS:

 

"E. Menini" Scholarship ‑ 1947

French Hospital Alumni Award ‑ 1959

A. and A. Sinsheimer Fund Award ‑ 1966‑1971

New York Health Research Council Award ‑ 1972‑1975

Fulbright Travel Grantee ‑ 1958‑62

New York State/UUP Excellence Award, 1991

 

HONORS:

 

Council on Basic Sciences of American Heart Association ‑ 1969‑

Libera Docenza in General Physiology, Italy ‑ 1971.

President, Electrophysiological Group ‑ 1972‑1973.

Board of Directors of the New York Heart Association ‑ 1978‑1984.

President, Downstate Medical Center Chapter of Sigma Xi, 1984.

Member of (PC)2 1971-2003

Doctorate Honoris Causa, University of Ferrara Italy, 1990.

Miembro Honorario, Sociedad Mexicana de Cardiologia, 1991.

A Gem Lecture at SUNY, HSC Brooklyn: Matters of the heart: an electrophysiological view. Dec 1, 1998.

Honorary Member, Associazione Nicolò Copernico- Alumni dell’Ateneo Estense, Italy.

 

LISTED IN:

 

Who's Who in the East

American Men and Women of Science

Dictionary of International Biography

Men of Achievement

Who's Who in Science and Engineering

Who’s Who in Medicine and Healthcare

Who’s Who in America

 

MEMBERSHIP IN SClENTIFIC SOClETlES:

 

American Physiological Society

Harvey Society

New York Academy of Sciences

New York and American Heart Associations

Cardiac Muscle Society

Cardiac Electrophysiological Group

Society of the Sigma Xi

International Study Group for Research in Cardiac Metabolism

 

PRINCIPAL FlELDS OF RESEARCH:

 

A. Electrophysiology

B. Cardiovascular Physiology

 

INVITED PARTICIPANT TO:

 

1.                   The Heart and Circulation, Second National Conference on Cardiovascular Disease. Washington, D.C. 1964 "Physiology: Electrophysiology of the Heart".

2.                   Symposium on Potassium and The Heart, Lexington, Ky. 1965.

3.                   Round Table on "Electrical and mechanical factors on normal and abnormal impulse formation" 1970, NIH, Bethesda, Md.

4.                   Symposium on Electrical Correlates of Clinical Arrhythmias, published in Am. J. Cardiology, 1971.

5.                   International Study Group for Research in Cardiac Metabolism, Winnipeg, Canada, 1972.

6.                   International Study Group for Research in Cardiac Metabolism, Quebec, Canada, 1974.

7.                   Electrophysiology Conference, Miami Beach, Florida, 1976.

8.                   Symposium on The Sinus Node. Structure, Function and Clinical Relevance, Maastricht, Holland, 1977.

9.                   Seventh International Congress of Pharmacology, Paris, France, 1978.

10.               Electrophysiology Conference, Hilton Head, South Carolina, 1978.

11.               New York Heart Clinical Conference Supraventricular Tachycardias: A Critical Evaluation, New York, NY 1979.

12.               International Symposium on Atrial Pacemakers, Augusta, Georgia, 1979.

13.               Symposium on Electrogenic Pumps, Yale University, 1979.

14.               Workshop in Cardiac Electrophysiology, Buenos Aires, Argentina, 1981.

15.               New Frontiers of Arrhythmias, Fifth International Congress, Marilleva, Italy, 1982.

16.               The Eight Asian‑Pacific Congress of Cardiology, Taipei, Taiwan, 1983.

17.               The New Frontiers of Arrhythmias, Sixth International Congress, Marilleva, Italy, 1984.

18.               International Symposium on Cardiac Arrhythmias, Amelia Island, Florida, May 1984.

19.               Bethesda Conference #15 Sudden Cardiac Death. Bethesda, Md., June 1984.

20.               International Symposium "Sick Sinus Syndrome Today" Milan, Italy, 1985.

21.               International Congress on "Arteriopathies in old age: Clinical and therapeutical problems" Nemi, Italy, 1985.

22.               The New Frontiers of Arrhythmias, Seventh International Congress, Marilleva, Italy, 1986.

23.               First International Symposium of Geriatric Cardiology, Naples, Italy, 1986.

24.               International Symposium on Cardiac Electrophysiology: Past, Present, and Future in Honor of Silvio Weidmann, Bern, Switzerland, September 10/11 1986.

25.               Second International Symposium of Geriatric Cardiology, Naples, Italy, November 1987.

26.               The New Frontiers of Arrhythmias, Eight International Congress, Marilleva, Italy, February 1988.

27.               Lo Scompenso Cardiaco nell'Anziano, Third International Symposium of Geriatric Cardiology, Naples,           Italy, November 1989.

28.               The New Frontiers of Arrhythmias. Ninth International Congress, Marilleva, Italy, February 1990.

29.               IV Congress of the Interamerican Society for Clinical Pharmacology and Therapeutics, Mexico City, Mexico, September 1990.

30.               Symposium in Honor of Prof. Brian F. Hoffman, Islamorada, FL, October 1990. Chairman of the Committee on Abnormal Automaticity.

31.              Fourth International Congress of Geriatric Cardiology, Naples, Italy, November 1991.

32.               XIV Congreso National de Farmacologia, Mexico City, Mexico, November 1991, Conferencia Magistral: On the mechanism of digitalis inotropy.

33.               The New Frontiers of Arrhythmias, Tenth International Congress, Marilleva, Italy, February 1992.

34.               European Working Group of Cardiac Cellular Electrophysiology, 16th Meeting, in Honor of Prof. A. Giotti, Ferrara, Italy, September 1992.

35.               The New Frontiers of Arrhythmias, 11th International Congress, Marilleva, Italy, February 1994.

36.               Instituto Nacional de Cardiologia, International Congress for the 50th Anniversary, Mexico City, Mexico, April 1994.

37.               Italian Society of Cardiovascular Research, Second National Congress, European Joint Session, Parma, Italy, September 1995.

38.               Symposium on Recent Advances in Studies of Cardiac Ion Channels and Arrhythmias, Tokyo, Japan, October 1995.

39.               The New Frontiers of Arrhythmias, 12th International Congress, Marilleva, Italy, February 1996.

40.               The New Frontiers of Arrhythmias, 13th International Congress, Marilleva, Italy, February 1998.

41.               Italian Society of Cardiovascular Research, Fifth National Congress, Rome, Italy, October 1998. Magistral Lecture: Electrophysiology and Cardioprotection.

42.               The New Frontiers of Arrhythmias, 14th International Congress, Marilleva, Italy, February 2000.

43.               The New Frontiers of Arrhythmias, 15th International Congress, Marilleva, Italy, April 2002.

44.               The New Frontiers of Arrhythmias, 16th International Congress, Marilleva, Italy, January 2004.

 

EDITORlAL APPOINTMENTS:

 

Associate Editor ‑ American Journal of Physiology: Heart and Circulatory Physiology, 1976‑1980.

Editorial Board  ‑ Circulation Research, 1974‑1980,

                 ‑ European J. Pharmacology, 1985‑1990

                 ‑ J. Electrocardiology, 1985‑

                 - New Trends in Arrhythmias, 1985-1997, Associate Editor, 1992-1997

                 - Journal of Biomedical Science, 1993-

 

EDITORlAL CONSULTANT

 

American Journal of Physiology

Circulation

Circulation Research

Cardiovascular Pharmacology

Science

Journal of Pharmacology and Experiment Therapeutics

European Journal of Pharmacology

Life Sciences

Cardiovascular Research

Heart Journal

 

NIH CONSULTANT

 

Ad Hoc member of the Pharmacology study section.    

Ad Hoc member NIH Site Visits.

Member, NIH Cardiopulmonary Study Section, 1981‑1985.

Ad Hoc member NIH Cardiopulmonary Study Section, February, 1988.

 

LOCAL COMMITTEE MEMBERSHIP

 

Committee on Academic and Professional Qualifications, 1970‑1972.

Departmental Committee on Academic and Professional Qualifications, 1973‑1976, Chairman.

Committee of the Faculty of the School of Graduate Studies, 1972‑1974, 1977‑1980.

Committee of the Faculty and Professional Staff, 1973‑1975.

Committee on Educational Policy and Curriculum Integration, 1973, Chairman.

Departmental Finance Committee, 1975‑1976, 1977‑1978. 

DMC Cardiac Group, President, 1976‑1977.

Departmental Committee on Academic and Professional Qualifications, 1981‑1983.

Committee of the Education Policy and Curriculum, 1985‑1987.

Committee on Small Grants, 1986‑1990

Presiding member of an Ad Hoc Committee for CAPQ, 1986.

Fourth‑year Basic Science-Clinical Correlations Committee, 1986.

Animal Care and Utilization Committee, 1986‑1990.

Committee on Academic and Professional Qualifications, 1987‑1990

Ad Hoc Committee for CAPQ, Chairman, 1988.

Technical Advisory Committee, Animal Facilities 1990

Committee on Academic and Professional Qualifications, Graduate School, 1990

Continuing Medical Education Advisory Committee, 1990

Liaison Member for the Faculty Assembly, 1990-1992

Liaison Member for the Search Committee for the Physiology Chair, 1989-1994

Committee for the comprehensive examination of Physiology graduate student, 1990.

Presiding Member for the Thesis Committee for G. Condemi, 1991.

Graduate Faculty Council, 1988-

Committee for C. McC. Brooks Summer Research Fellowships, 1990- 

Committee for Schoolwide Summer Research Fellowship for Medical Students, 1992-.

Pharmacology Committee for comprehensive examination, 1990.

Committee for the selection of Graduate Students Fellowships, 1992. 

Ad Hoc Committee for the CAPQ, June 1992.

Admission Committee of the Graduate Program in Physiology.

Committee on Academic and Professional Qualifications, 1994-1997.

Ad Hoc Committee for the CAPQ, June 1996.

Transition Committee of the Graduate School 1997.

Ad Hoc Committee for the CAPQ, February 1998.

Presiding Member for the Thesis Committee for Boyu Huang, 1998.

Presiding Member for the Thesis Committee for Jianxin Shi, 1998.

Presiding Member for the Thesis Committee for Jian Feng, 1998.

Presiding Member for the Thesis Committee for Jianxin Shen, 1998.

Ad Hoc Committee for the CAPQ, Dec.1999.

Presiding Member for the Thesis Committee for Guang Xiao, 2002.

 

PUBLICATIONS

 

BOOKS

 

1.                   Research in Physiology ‑ A Liber Memorialis in Honor of Prof. C. McC. Brooks; edited by F.F. Kao, K. Koizumi and M. Vassalle. A. Gaggi, Publisher, Bologna, Italy, 1971.

 

2.                   Cardiac Physiology for the Clinician, edited by M. Vassalle, Academic Press, New York, 1976.

2a.        Cardiac Physiology for the Clinician, edited by M. Vassalle, translated in Chinese in 1978.

 

3.                   Excitation and Neural Control of the Heart, edited by M. N. Levy and M. Vassalle. American Physiological Society, Bethesda, Maryland. 1982.

 

4.                   "Chandler McCuskey Brooks: The Scientist and The Man", edited by M. Vassalle. State University of New York, Health Science Center at Brooklyn, 1990.

 

5.                   Vassalle, M. Diario di un Fisiologo del Cuore. Nuova York, 1992. (Includes philosophical essays).

 

6.                   Vassalle, M. Emozioni perdute/Lost Emotions. New York, 1994. (Poems in Italian and in the English translation).

 

7.                   Vassalle, M. L’Enigma della Mente: Aforismi/ The Riddle of the Mind: Aphorisms. New York, 1996

 

8.                  Vassalle, M. La Realtà dell’Io: Aforismi/ The Reality of the Self: Aphorisms. New York 2000. 

8a.             Vassalle, M. La Realtà dell’Io: Aforismi (published by Editing s.a.s., Treviso, 2006 in a collection edited by Paolo Ruffilli).

 

9.                   Vassalle, M., Dune/Dunes. (Poems in Italian and in the English version). New York, 2001.

 

10.               Vassalle, M., Penombre/Twilights. (Poems in Italian and in the English version). New York, 2003.

 

11.              Vassalle, M. Non Sempre/Not Always. (Poems in Italian and in the English version). New York, 2004.

11a.   Vassalle, M. Non Sempre. (Poems in Italian) published by Editing s.a.s., Treviso, 2005 in a collection edited by Paolo Ruffilli.

 

12.      Vassalle M. Foglie d’Autunno (Aforismi e Riflessioni). Publlished by Maremmi Editori, Firenze Libri, Firenze, 2006.

 

REVlEWS AND CHAPTERS

 

1.               Vassalle, M. Automaticity and automatic rhythms. Am. J.  Cardiol. 28: 245‑252, 1971.

 

2.         Vassalle, M. Electrophysiology of the heart cells. In: Cardiac Physiology for the Clinician, Ed. M. Vassalle, Academic Press, New York, pp. 1‑26, 1976.

 

3.                   Vassalle, M. Cardiac Automaticity. In: Cardiac Physiology for the Clinician, Ed. M. Vassalle, Academic Press, New York, pp. 27‑59. 1976.

 

4.         Vassalle, M. and E. Musso. Therapeutic and toxic actions of digitalis. In: Cardiac Physiology for the Clinician, Ed. M. Vassalle, Academic Press, New York, pp. 203‑239, 1976.

 

5.         Vassalle, M. Electrophysiological basis of digitalis arrhythmias, Part I. CVP 4: 21‑23 + p. 37, 1976.

 

6.         Vassalle, M. Electrophysiological basis of digitalis arrhythmias, Part II. CVP 5: 25‑31 + p. 34, 1977.

 

7.         Vassalle, M. Generation and conduction of impulses in the heart under physiological and pathological conditions. Pharmac. Ther. B. 3: 1‑39, 1977.

 

8.         Vassalle, M. Cardiac automaticity and its control. Am. J. Physiol. Heart and Circulatory Physiology 2: H625‑H634, 1977.

 

9.         Vassalle, M. The relationship among cardiac pacemakers: overdrive suppression. Circ. Res. 41: 269‑277, 1977.

 

10.        Vassalle, M. The acceleratory action of the vagus on the sinus node. In: The Sinus Node. Structure, Function and Clinical Relevance. Ed. F.I.M. Bonke. M. Nijhoff, BV Publishers, The Hague, 1978, section III: Electrophysiology of the sinus node, pp. 279‑289, 1978.

 

11.        Vassalle, M. Arrhythmias caused by cardiac glycosides. In: Advances in Pharmacology and Therapeutics, vol. 6, Clinical Pharmacology Ed. P. Duchène‑Marullaz, Pergamon Press, Oxford and New York, pp. 221‑230, 1979.

 

12.        Vassalle, M. Electrogenesis of the plateau and pacemaker potential. Ann. Rev. Physiol. 41: 425‑440, 1979.

 

13.               Vassalle, M. The Human Heart. Carolina Biology Readers, Ed. J.J. Head, Carolina Biological Supply Co., Burlington, N.C. 1979.

 

14.        Vassalle, M. Effect of pharmacological interventions on atrial pacemakers. In: Physiology of Atrial Pacemakers and Conductive Tissues, Ed. Robert C. Little, Futura Publishing Co. Inc., New York, pp. 315‑337, 1980.

 

15.        Vassalle, M. The role of the slow inward current in impulse formation. In: The Slow Inward Current and Cardiac Arrhythmias, Ed. D.P. Zipes, J.C. Bailey and V. Elharrar, The Hague, Martinus Nijhoff Publishers, pp. 127‑148, 1980.

 

16.        Vassalle, M. The role of the electrogenic sodium pump in controlling excitability in nerve and cardiac fibers. In: Electrogenic Ion Pumps, Ed. C. L. Slayman, Academic Press, New York, pp. 467‑483, 1982.

 

17.        Vassalle, M. Cardiac automaticity and its control. In: Excitation and Neural Control of the Heart. Ed. M.N. Levy and M. Vassalle, American Physiological Society, Bethesda, Maryland, pp. 59‑77, 1982..

 

18.        Vassalle, M. Concetti attuali sull'automatismo cardiaco normale e anormale. In: Proceeding 5th Intern. Congress Cardiol: Le Nuove Frontiere delle Aritmie, Vol. IV., Ed. F. Furlanello, R. Bettini, P. Dalforno, M. Disertori, G. Vergara and G. Iname, Piccin Publisher, Padova, Italy, pp. 3‑17, 1982.

 

19.        Vassalle, M. Physiological basis of normal and abnormal automaticity. In: Frontiers of Cardiac Electrophysiology, Ed. M.B. Rosenbaum and M.V. Elizari, Martinus Nijhoff Publishers, Boston, pp. 120‑143, 1983.

 

20.        Vassalle, M. The role of calcium in normal and abnormal cardiac electrogenesis. Acta Medica Romana, 21: 226‑244, 1983.

 

21.               Vassalle, M. The mechanism of induction of the oscillatory potential in arrhythmias. In: Procedings 6th Intern. Congress Cardiol: The New Frontiers of Arrhythmias. Ed. F. Furlanello and M. Disertori, O.I.C. Medical Press, Florence, Italy, pp. 71‑78, 1984.

 

22.        Vassalle, M. Cardiac automaticity in normal and some abnormal conditions. In: Tachycardias, Ed. B. Surawicz, C.P. Reddy and E.N. Prystowsky, pp. 55‑65, 1984.

 

23.        Vassalle, M. Overdrive excitation: The onset of spontaneous activity following a fast drive. In: Cardiac Electrophysiology and Arrhythmias. Ed. D.P. Zipes and J. Jalife. Grune and Stratton, Inc., 1985, pp. 97‑107.

 

24.        Vassalle, M. Effetti biocellulari dei farmaci sul nodo del seno. Proc. Intern. Symposium on "Sick Sinus Syndrome Today" pp 43‑50. O.I.C., Milan, Italy. 1985.

 

25.        Vassalle, M. On the mechanisms underlying cardiac standstill: Factors determining success or failure of escape pacemakers in the heart. J. Am. Coll. Cardiol. 5: 35B‑42B, 1985.

 

26.        Vassalle, M. and P. Carbonin. Electrophysiological basis of cardiac arrhythmias. In: New Trends in Arrhythmias. 1: 5‑26, 1985.

27.        Carbonin, P. and M. Vassalle. Cardiac arrhythmias in man: An overview of pathogenetic concepts. In: New Trends in Arrhythmias. 1: 27‑40, 1985.

 

28.        Vassalle, M. Electrophysiological and ionic bases of overdrive excitation. In: New Trends in Arrhythmias. 1: 197‑200, 1986.

 

29.        Abete, P. and M. Vassalle. Intracellular sodium activity, strophanthidin inotropy and arrhythmias under conditions that vary cellular sodium. In: New Trends in Arrhythmias. 2: 101‑103, 1986.

 

30.        Vassalle, M. Cardiac glycosides: regulation of force and rhythm. In: Cardiac Muscle. Regulation of Excitation and Contraction. Ed. R.D. Nathan, Academic Press, New York, 1986, pp. 237‑267.

 

31.        Vassalle, M. The relationship between rate and electrical activity in the heart: arrhythmogenic and antiarrhythmic effects. In: Cardiovascular Pharmacology, 87. Results, Concepts and Perspectives. Ed. J. Papp, Gy. Akademiai Kiado, Budapest, 1987.

 

32.        Vassalle, M. Contribution of the Na+/K+‑pump to the membrane potential. Experientia 43: 1135‑1140, 1987.

 

33.        Vassalle, M. I movimenti ionici in corso di cardiomiopatia ischemica. Atti 2o Simposio Internazionale di Cardiogeriatria, Napoli, 1987, pp. 11-18.

 

34.        Vassalle, M., H. Apfel, and G. Iacono. Acetylcholine‑induced overdrive excitation and its mechanism. Proc. Eighth International Congress: "The New Frontiers of Arrhythmias". 4: 87‑92, 1988.

 

35.        Vassalle, M. I meccanismi delle tachiaritmie nell'anziano. La Riforma Medica 103: 87‑96, 1988.

 

36.        Vassalle, M. Autonomic regulation of the heart at rest and during exercise. Sports Cardiology 2: 1-16, 1989.

 

37.        Vassalle, M. Aspetti elettrofisiologici della terapia digitalica. Atti 3rd International Symposium Geriatric Cardiology, Giornale Italiano di Gerontologia. 1990.

 

38.        Vassalle, M. Overdrive excitation in the sinus node. New Trends in Arrhythmias. 6: 507-512, 1990

 

39.        Vassalle, M. Overdrive suppression and overdrive excitation. In Cardiac Electrophysiology: A textbook. Eds. M.R. Rosen, M.J. Janse and A.L. Wit. Futura Publishing Co., Inc., Mount Kisco, NY 1990. Section 2.2 pp. 1-15.

 

40.        Vassalle, M. Arritmias de origen ectopico: bases fisiopatologicas para su tratamiento. Archivos Instituto Cardiologia Mexico. 61: 455-463, 1991.

 

41.        Vassalle, M. Ruolo dei cationi nella cardiopatia ischemica. Atti Congr. Intern. Cardiogeratria. 93-106, 1992

 

42.        Vassalle, M. The ionic mechanism underlying the pacemaker potential in cardiac Purkinje fibers. New Trends in Arrhythmias. 9: 683-688, 1993.

 

43.        Vassalle, M. and F. Valenzuela. Role of the negative slope of the inward K+ rectifier in the early afterdepolarization. New Trends in Arrhythmias. 9: 715-720, 1993.

 

44.        Vassalle, M. The pacemaker current (If) does not play an important role in regulating SA node pacemaker activity. Cardiovasc. Res. 30: 309-310, 1995. (Cardiovascular Controversies).

 

45.        Vassalle, M. The block of potassium channels by cesium and the pacemaker current in cardiac Purkinje fibers. In: Potassium Channels in Normal and Pathological Conditions. Eds. J. Vereecke, PP. van Bogaert and F. Verdonck, Leuven University Press, 1995, pp. 420-423.

 

46.        Vassalle, M. Dual pacemaker mechanisms in the sino-atrial node. New Trends in Arrhythmias, 1-4: 130-134, 1995.

 

47.        Vassalle, M. The role of K+ in the pacemaker current in cardiac Purkinje fibers. New Trends in Arrhythmias, 1-4: 145-149, 1995.

 

48.        Vassalle, M. Mechanisms underlying the sino-atrial resistance to high [K+]o. G. Ital. Cardiol. 28, Suppl 1: 159-164, 1998.

 

49.        Vassalle M., Yu H. and I.S. Cohen. Pacemaker channels and cardiac automaticity. In: Zipes DP and Jalife J, eds, Cardiac Electrophysiology. From Cell to Bedside. Philadelphia: WB Saunders Company, 94-103, 1999.

 

50.        Vassalle, M. Rapporti tra elettrofisiologia e cardioprotezione. Cardiologia 44: 521-534, 1999.

 

51.        Vassalle, M. and D.E. Berg. Mechanisms underlying the initiation of normal and abnormal automaticity in Purkinje fibers. G. It. Cardiol. 29 (Suppl. 5): 75-79, 1999.

 

52.        Vassalle, M. Sino-atrial node pacemaker currents and their control. G. It. Aritmol. Cardiostim.5 (Suppl. 1):17- 22, 2002.

 

53.        Vassalle, M. Mechanisms underlying cardiac pacemaker activity. J. Med. Sci. 23: 249-264, 2003.

 

54.        Vassalle, M. Obligatory role of voltage oscillations in cardiac pacemaker discharge. Ital. Heart J. 5 (S 1): 5-56, 2004.

 

55.        Vassalle, M. and C.-I Lin. Calcium overload and cardiac function. J. Biomed. Sci. 11:542-565, 2004.

 

 

MISCELLANEOUS

 

1.                   Vassalle, M. The problems of the heart: views of an electrophysiologist. An address delivered at the bestowal of a Laurea ad Honorem in the occasion of the 600th Anniversary of the University of Ferrara, Italy. Published in M. Vassalle, "Emozioni Perdute/Lost Emotions" pp. 237-245, 1994.

 

2.                   Vassalle, M. Cesium and the pacemaker current: a reply. J. Cardiovasc. Electrophysiol. 6: 1153-1155, 1995 (reply to a Letter to the Editor).

 

3.                   Vassalle, M. Letter about the Physiology Curriculum for Medical Students in the ANews From Senior Physiologists.  Physiologist. 42:102, 1999.

 

4.                   Vassalle M. Matters of the Heart: an Electrophysiological View. (Highlights of the Gem Lecture). Alumni Today, Spring 1999, pp. 29-31.

 

5.                   Vassalle M. Relation among space, time and movement. Published in M. Vassalle,  La realtà dell’Io: Aforismi/The Reality of the Self: Aphorisms, pp. 239-246, 2000.

 

6.                   Vassalle M. Art. Published in M. Vassalle, La realtà dell’Io: Aforismi/The Reality of the Self: Aphorisms, pp.  270-292, 2000.

 

7.                   Vassalle, M. , Reality, the Mind and Poetry, published in M. Vassalle, "Non Sempre/Not Always", pp. 371-389, 2004.

 

 

 ORIGINAL PAPERS

 

1.                   Baschieri, L., P. Lotti and M. Vassalle. Rilievi sull'azione ipotensiva della reserpina. Il Progresso Medico 11: 260‑269, 1955.

 

2.                   Lotti, P. and M. Vassalle. Una non comune registrazione fonagrafica in un caso di pneumotorace spontaneo. Rass. Fisiop. Clin. Terap. 27: 750‑754, 1955.

 

3.                   Bascheri, L., P. Lotti and M. Vassalle. Effetti dell'inalazione di ossigeno su l'emodinamica generale. Rass. Fisiop. Clin. Terap. 28: 425‑442, 1956.

 

4.                   Lotti, P., M. Vassalle and P. Di Leo. Effetti della inalazione di ossigeno sul balistocardiogramma patologico. Rass. Fisiop. Clin. Terap. 28: 917‑929, 1956.

 

5.                   Pallone, E. and M. Vassalle. Influenza dei sulfamidici antidiabetici su la utilizzazione di glucosio in vitro da parte del tessuto muscolare. Folia Endocrinologica 9: 775‑779, 1956.

 

6.                   Baschieri, L., R.D. Ricci, G.F. Mazzuoli and M. Vassalle. Studi sulla portata epatica nell'uomo: modificazione del flusso epatico da digitale. Cuore e Circolazione 41: 103‑115, 1957.

 

7.                   Lotti, P. and M. Vassalle. Modificazioni circolatorie indotte dallo pneumoperitoneo in ammalati di tubercolosi polmonare. Rass. Fisiop. Clin. Terap. 29: 721‑737, 1957.

 

8.                   Vassalle, M., D. Biancalana and P. Lotti. II balistocardiogramma dell'adolescente. Rass. Fisiop. Clin. Terap. 29: 290‑297, 1957.

 

9.                   Biancalana, D. and M. Vassalle. La sindrome di Takayashu; rilievi clinici ed emodinamici. Rass. Fisiop. Clin. Therap. 30: 969‑983, 1958.

 

10.               Biancalana, D., G.P. Zucchelli and M. Vassalle. La prova dell'ormone tireotropo nel morbo di Basedow e nelle sindromi basedowiane incomplete. Folia Endocrinologica 11: 718‑729, 1958.

 

11.               Vassalle, M., P. Lotti and D. Biancalana. Adattamenti circolatori al carico di lavoro moderato e strenuo nel soggetto allenato all'esercizio fisico. Rass. Fisiop. Clin. Terap. 30: 1216‑1232, 1958.

 

12.               Lotti, P. and M. Vassalle. Modificazioni emodinamiche indotte dall'ipnosi negli ipermetabolismi. Folia Endocrinologica 12: 230‑252, 1959.

 

13.               Rossi, A. and M. Vassalle. Su di un caso di sindrome di Laurence‑Moon‑Bardet­-Biedl. Rass. It. Ottalm. 11: 412‑426, 1959.

 

14.               Vassalle, M. Indagine intorno all'attività cardiovascolare di un estratto di cuore. Rass. Fisiopat. 31: 165‑176, 1959.

 

15.               Vassalle, M., N. Perna and P. Lotti. Infarto miocardico acuto. Il Policlinico 67: 381­-392, 1960.

 

16.               Vassalle, M. Role of catecholamine release in morphine hyperglycemia. Am. J. Physiol. 200: 530‑534, 1961.

 

17.               Vassalle, M., J. Karis and B.F. Hoffman. Toxic effects of ouabain on Purkinje fibers and ventricular muscle fibers. Am. J. Physiol. 203: 433‑439, 1962.

 

18.               Vassalle, M. and K. Greenspan. Effects of potassium on ouabain‑induced arrhythmias. Am. J. Cardiol. 12: 692‑701, 1963.

 

19.               Vassalle, M., K. Greenspan and B.F. Hoffman. An analysis of arrhythmias induced by ouabain in intact dogs. Circ. Res. 13: 132‑148, 1963.

 

20.               Vassalle, M., K. Greenspan, S. Jomain and B.F. Hoffman. Effect of potassium on automaticity and conduction of canine heart. Am. J. Physiol. 207: 334‑340, 1964.

 

21.               Vassalle, M. and B.F. Hoffman. The spread of sinus activation during potassium administration. Circ. Res. 17: 285‑295, 1965.

 

22.               Vassalle, M. Cardiac pacemaker potentials at different extra‑ and intracellular K concentrations. Am. J. Physiol. 208: 770‑775, 1965.

 

23.               Vassalle, M. An analysis of cardiac pacemaker potential by means of a "voltage clamp" technique. Am. J. Physiol. 210: 1335‑1341, 1966.

 

24.               Vassalle, M., D.L. Caress, A.J. Slovin and J. H. Stuckey. On the cause of ventricular asystole during vagal stimulation. Circ. Res. 20: 228‑241, 1967.

 

25.               Vassalle, M., F.J. Vagnini, A. Gourin and J.H. Stuckey. Suppression and initiation of idioventricular automaticity during vagal stimulation. Am. J. Physiol. 212: 1‑7, 1967.

 

26.               Copen, D.L., D.P. Cirillo and M. Vassalle. Tachycardia following vagal stimulation. Am. J. Physiol. 215: 696‑703, 1968.

 

27.               Vassalle, M., M.J. Levine and J. H. Stuckey. On the sympathetic control of ventricular automaticity: the effects of stellate ganglion stimulation. Circ. Res. 23: 249‑258, 1968.

 

28.               Vassalle, M., J.H. Stuckey and M.J. Levine. Sympathetic control of ventricular automaticity: role of the adrenal medulla. Am. J. Physiol. 217: 930‑937, 1969.

 

29.               Stuckey, J.H., M.J. Levine and M. Vassalle. On the sympathetic control of ventricular automaticity: the effects of a reflex increase of sympathetic discharge. Am. J. Cardiol. 23: 822‑829, 1969.

 

30.               Polimeni, P.I. and M. Vassalle. Potassium fluxes in Purkinje and ventricular muscle fibers during rest and activity. Am. J. Physiol. 218: 1381‑1388, 1970.

 

31.               Vassalle, M. Electrogenic suppression of automaticity in sheep and dog Purkinje fibers. Circ. Res. 27: 361‑377, 1970.

 

32.               Vassalle, M., W. Mandel and M.S. Holder. Catecholamine stores under vagal control. Am. J. Physiol. 218: 115‑123, 1970.

 

33.               Carpentier, R. and M. Vassalle. Enhancement and inhibition of a frequency‑activated electrogenic sodium pump in cardiac Purkinje fibers. In: Research in Physiology, A Liber Memorialis in Honor of Prof. C. McC. Brooks. Ed. F. F. Kao, K. Koizumi and M. Vassalle. Gaggi Publisher, Bologna, 1971, pp. 81-98.       

 

34.               Polimeni, P.I. and M. Vassalle. On the mechanism of ouabain toxicity in Purkinje and ventricular muscle fibers at rest and during activity. Am. J. Cardiol. 27: 622‑629, 1971.

 

35.               Vassalle, M. and O., Barnabei. Norepinephrine and potassium fluxes in cardiac Purkinje fibers. Pflügers Arch. 322: 287‑303, 1971.

 

36.               Vassalle, M. and R. Carpentier. Hyperpolarizing and depolarizing effects of norepinephrine in cardiac Purkinje fibers. In: Research in Physiology, A Liber Memorialis in Honor of Prof. C. McC. Brooks. Ed. F. F. Kao, K. Koizumi and M. Vassalle. Gaggi Publisher, Bologna, 1971, pp.373-388.

 

37.               Vassalle, M. and R. Carpentier. Overdrive excitation: the initiation of spontaneous activity in Purkinje fibers following a fast drive in the presence of norepinephrine. Pflügers Arch. 332: 198‑205, 1972.

 

38.               Holder, M.S., M.A. Anolik and M. Vassalle. Positive chronotropic effect of vagus on sinus node. Arch. Sci. Biol. 55: 103‑118, 1971.

 

39.               Posner, P. and M. Vassalle. The inhibitory action of norepinephrine on potassium uptake in cardiac Purkinje fibers. T.‑I.‑T.J. Life Sciences 1: 67‑78, 1971.

 

40.               Carpentier, R. and M. Vassalle. Restoration of electrical activity of guinea pig atria in hypothermia: effects of norepinephrine and electrical stimulation on membrane potentials. Circ. Res. 31: 507‑519, 1972.

 

41.               Vassalle, M., C. Ottolenghi, R. Manservigi and O., Barnabei. Glycogen metabolism and its control by norepinephrine in cardiac Purkinje fibers. Arch. Sci. Biol. 56: 97­-114, 1972.

 

42.               Vassalle, M., J.K. Greineder and J.H. Stuckey. Role of the sympathetic nervous system in the sinus node resistance to high potassium. Circ. Res. 32: 348‑354, 1973.

 

43.               Pliam, M.B., D.J. Krellenstein, M. Vassalle and C. McC. Brooks. Influence of the sympathetic system on the pacemaker suppression which follows overdrive. Circ. 48: 313‑321, 1973.

 

44.               Borasio, P.G. and M. Vassalle. Dibutyryl cyclic AMP and potassium transport in cardiac Purkinje fibers. Am. J. Physiol. 226: 1232‑1237, 1974.

 

45.               Borasio, P.G. and M. Vassalle. Effects of norepinephrine on active K transport and automaticity in cardiac Purkinje fibers. In: Recent Advances in Studies on Cardiac Structure and Metabolism. Vol. 4, Myocardial Biology, Ed. N. S. Dhalla, Baltimore, University Park Press, 1974 pp. 41-57.

 

46.               Krellenstein, D.J., M.B. Pliam, C. McC. Brooks and M. Vassalle. On the mechanism of idioventricular pacemaker suppression by fast drive. Circ. Res. 35: 923‑934, 1974.

 

47.               Pliam, M.B., D.J. Krellenstein, M. Vassalle and C. McC. Brooks. The influence of norepinephrine, reserpine and propranolol on overdrive suppression. J. Electrocardiol. 8: 17‑24, 1975.

 

48.               Borasio, P. G. and M. Vassalle. Inhibition of potassium uptake by low concentrations of norepinephrine and dibutyryl cyclic AMP. Arch. Internat. Physiologie Biochimie 83: 79‑97, 1975.

 

49.               Musso, E. and M. Vassalle. Inhibitory action of acetylcholine on potassium uptake of the sinus node. Cardiovasc. Res. 9: 490‑497, 1975.

 

50.               Vassalle, M. and E. Musso. On the mechanisms underlying digitalis toxicity in cardiac Purkinje fibers. In: Recent Advances in Studies on Cardiac Structure and Metabolism Volume 9 The Sarcolemma, Ed. P.‑E. Roy and N. S. Dhalla, University Park Press, Baltimore, pp. 355‑376, 1976.

 

51.               Vassalle, M., M. Cummins, C. Castro and J. H. Stuckey. The relationship between overdrive suppression and overdrive excitation in ventricular pacemakers in dogs. Circ. Res. 38: 367‑374, 1976.

 

52.               Vassalle, M., R.E. Knob, G.A. Lara and J. H. Stuckey. The effect of adrenergic enhancement on overdrive excitation. J. Electrocardiol. 9: 335‑343, 1976.

 

53.               Pliam, M.B., D.J. Krellenstein, C. McC. Brooks and M. Vassalle. Norepinephrine, potassium and overdrive suppression. Basic Res. Cardiol. 72: 34‑45, 1977.

 

54.               Vassalle, M., R.E. Knob, M. Cummins, G.A. Lara, C. Castro and J.H. Stuckey. An analysis of fast idioventricular rhythm in the dog. Circ. Res. 41: 218‑226, 1977.

 

55.               Lipsius, S.L. and M. Vassalle. Effects of acetylcholine on potassium movements in the guinea pig sinus node. J. Pharmacol. Exptl. Therap. 201: 669‑677, 1977.

 

56.               Lipsius, S.L. and M. Vassalle. Acetylcholine‑norepinephrine interactions on potassium movements in the sinus node. Europ. J. Pharmacol. 45: 35‑44, 1977.

 

57.               Musso, E. and M. Vassalle. Evidence for a nicotinic receptor in the sinus node. Europ. J. Pharmacol. 46: 1‑8, 1977.

 

58.               Vassalle, M., D.J. Krellenstein, M.B. Pliam and C McC. Brooks. Potassium‑related humoral transmission of overdrive suppression. J. Mol. Cell. Cardiol. 9: 921‑931, 1977.

 

59.               Krellenstein, D.J., M.B. Pliam, C. McC. Brooks and M. Vassalle. Factors affecting overdrive suppression of idioventricular pacemakers and associated potassium shifts. J. Electrocardiol. 11: 3‑10, 1978.

 

60.               Musso, E. and M. Vassalle. Effects of norepinephrine, calcium and rate of discharge on 42K movements in canine cardiac Purkinje fibers. Circ. Res. 42: 276‑284, 1978.

 

61.               Musso, E. and M. Vassalle. The action of theophylline on potassium uptake in cardiac Purkinje fibers. Cardiology 62: 322‑331, 1977.

 

62.               Lin, C.-I and M. Vassalle. Role of sodium in strophanthidin toxicity of Purkinje fibers. Am. J. Physiol. 234: H477‑H486, 1978.

 

63.               Lipsius, S.L. and M. Vassalle. Characterization of a two‑component upstroke in the sinus node subsidiary pacemakers. In: The Sinus Node, Structure, Function and Clinical Relevance. Ed. F.l. M. Bonke, M. Nijhoff, BV Publishers, The Hague, section three: Electrophysiology of the Sinus Node. pp. 233‑244, 1978.

 

64.               Loeb, J.M. and M. Vassalle. An analysis of cholinergic involvement in postvagal tachycardia. Cardiology 63: 270‑279, 1978.

 

65.               Lipsius, S.L. and M. Vassalle. Dual excitatory channels in the sinus node. J. Mol. Cell. Cardiol. 10: 753‑767, 1978.

 

66.               Carpentier, R. and M. Vassalle. Actions and interactions of norepinephrine and acetylcholine on sinus node potassium movements. Arch. Sci. Biol. 61: 75‑88, 1977.

 

67.               Lin, C.-I and M. Vassalle. Sodium lack prevents strophanthidin toxicity in Purkinje fibers. Cardiology 64: 110‑121, 1979.

 

68.               Loeb, J.M. and M. Vassalle. Adrenergic mechanisms in post vagal tachycardia. J. Pharmacol. Exp. Ther. 210: 56‑63, 1979.

 

69.               Vassalle, M. and C.-I Lin. Effect of calcium on strophanthidin‑induced electrical and mechanical toxicity in cardiac Purkinje fibers. Am. J. Physiol. 236: H689‑H697, 1979.

 

70.               Lin, C.-I and M. Vassalle. The antiarrhythmic effect of potassium and rubidium in strophanthidin toxicity. Europ. J. Pharmac. 62: 1‑15, 1980.

 

71.               Lin, C.-I and M. Vassalle. The effect of lithium on strophanthidin toxicity in cardiac Purkinje fibers. Proc. Soc. Exp. Biol. Med. 164: 212‑216, 1980.

 

72.               Vassalle, M. and M. Bhattacharyya. Local anesthetics and the role of sodium in the force development by canine ventricular muscle and Purkinje fibers. Circ. Res. 47: 666‑674, 1980.

 

73.               Bhattacharyya, M. and M. Vassalle. Metabolism‑dependence of overdrive‑induced hyperpolarization. Arch. int. Pharmacodyn. Therap. 246: 28‑37, 1980.

 

74.               Bhattacharyya, M.L. and M. Vassalle. The effect of local anaesthetics on strophanthidin toxicity in canine cardiac Purkinje fibres. J. Physiol. (London) 312: 125‑142, 1981.

 

75.               Vassalle, M. and A. Mugelli. An oscillatory current in sheep cardiac Purkinje fibers. Circ. Res. 48: 618‑631, 1981.

 

76.               Bhattacharyya, M. L. and M. Vassalle. Role of calcium and sodium in strophanthidin inotropy in cardiac Purkinje fibers. Am. J. Physiol. 240: H561‑H570, 1981.

 

77.               Bhattacharyya, M. L. and M. Vassalle. The effect of metabolic inhibitors on strophanthidin‑induced arrhythmias and contracture in cardiac Purkinje fibers. J. Pharmacol. Exp. Ther. 219: 75‑84, 1981.

 

78.               Vassalle, M. and M. L. Bhattacharyya. Interactions of norepinephrine and strophanthidin in cardiac Purkinje fibers. Internat. J. Cardiol. 1: 179‑194, 1981.

 

79.               Musso, E. and M. Vassalle. The role of calcium in overdrive suppression of canine cardiac Purkinje fibers. Circ. Res. 51: 167‑180, 1982.

 

80.               Bhattacharyya, M.L. and M. Vassalle. Effect of tetrodotoxin on electrical and mechanical activity of cardiac Purkinje fibers. J. Electrocardiol. 15: 351‑360, 1982.

 

81.               Ishikawa, S. and M. Vassalle. Different forms of spontaneous discharge induced by strophanthidin in cardiac Purkinje fibers. Am. J. Physiol 243: H767‑H778, 1982.

 

82.               Lee, C.O, and M. Vassalle. Modulation of intracellular Na+ activity and cardiac force by norepinephrine and Ca2+. Am. J. Physiol. 244: C11O‑C114, 1983.

 

83.               Lin, C.‑I and M. Vassalle. Role of calcium in the inotropic effects of caffeine in cardiac Purkinje fibers. Internat. J. Cardiol. 3: 421‑434, 1983.

 

84.               Li, T. and M. Vassalle. Sodium‑calcium exchange in Purkinje fibers: electrical and mechanical effects. Basic Res. Cardiol. 78: 396‑414, 1983.

 

85.               Valenzuela, F. and M. Vassalle. Interaction between overdrive excitation and overdrive suppression in canine Purkinje fibres. Cardiovasc. Res. 17: 608‑619, 1983.

 

86.               Vassalle, M. and M. Di Gennaro. Caffeine eliminates the oscillatory current in cardiac Purkinje fibres. Europ. J. Pharmacol. 94: 361‑362, 1983.

 

87.               Lin, C.‑I and M. Vassalle. Calcium overload and strophanthidin‑induced mechanical toxicity in cardiac Purkinje fibers. Can. J. Physiol. Pharmacol. 61: 1329‑1339, 1983.

 

88.               Vassalle, M. and C.O. Lee. The relationship among intracellular sodium activity, calcium, and strophanthidin inotropy in canine cardiac Purkinje fibers. J. Gen. Physiol. 83: 287‑307, 1984.

 

89.               Li, T. and M. Vassalle. The negative inotropic effect of calcium overload in cardiac Purkinje fibers. J. Mol. Cell. Cardiol. 16: 65‑77, 1984.

 

90.               Bernabei, R. and M. Vassalle. The inotropic effects of strophanthidin in Purkinje fibers and the sodium pump. Circ. 69: 618‑631, 1984.

 

91.               Paspa P. and M. Vassalle. Mechanism of caffeine‑induced arrhythmias in canine cardiac Purkinje fibers. Am. J. Cardiol. 53: 313‑319, 1984.

 

92.               Di Gennaro, M., P. Carbonin and M. Vassalle. On the mechanism by which caffeine abolishes the fast rhythms induced cardiotonic steroids. J. Mol. Cell. Cardiol. 16: 851‑862, 1984.

 

93.               Vassalle, M. and M. Di Gennaro. Caffeine actions on currents induced by calcium­ overload in Purkinje fibers. Europ. J. Pharmacol. 106: 121‑131, 1984.

 

94.               Di Gennaro, M. and M. Vassalle. Role of calcium on the actions of caffeine in ventricular muscle fibers. J. Cardiovasc. Pharmacol. 6: 739‑747, 1984.

 

95.               Valenzuela, F. and M. Vassalle. Overdrive excitation and cellular calcium load in canine cardiac Purkinje fibers. J. Electrocardiol. 18: 21‑34, 1985.

 

96.               Satoh, H. and M. Vassalle. Reversal of caffeine‑induced calcium overload in cardiac Purkinje fibers. J. Pharmacol. Exper. Ther. 234: 172‑179. 1985.

 

97.               Di Gennaro, M. and M. Vassalle. Relationship between caffeine effects and calcium in canine cardiac Purkinje fibers. Am. J. Physiol. 249: H520‑H533, 1985.

 

98.               Ishikawa, S. and M. Vassalle. Reversal of strophanthidin negative inotropy by metabolic substrates in cardiac Purkinje fibers. Cardiovasc. Res. 19: 537‑551, 1985.

 

99.               Lee, C.O., P. Abete, M. Pecker, J.K. Sonn and M. Vassalle. Strophanthidin inotropy: Role of intracellular sodium ion activity and sodium‑calcium exchange. J. Mol. Cell. Cardiol. 17: 1043‑1053, 1985.

 

100.            Abete, P. and M. Vassalle. The role of intracellular sodium activity in the inotropy potentiation among high [Ca]o, norepinephrine and strophanthidin. Archives Intern. Pharmacodyn. Ther. 278: 87‑96, 1985.

 

101.            Li, T., R. Bernabei, P. Carbonin and M. Vassalle. Strophanthidin inotropy in cardiac Purkinje fibers under conditions that vary cellular sodium or calcium. Can. J. Physiol. Pharmacol. 64: 1385‑1394, 1986.

 

102.            Di Gennaro, M., M. Vassalle, G. Iacono, M. Pahor, R. Bernabei and P.U. Carbonin. On the mechanisms by which hypoxia eliminates digitalis‑induced tachyarrhythmias. Europ. Heart J. 7: 341‑352, 1986.

 

103.            Hasegawa, J. and M. Vassalle. Enhancement and suppression of currents related to calcium‑overload by different concentrations of methylxanthines. Archives Internat. Pharmacodyn. Therap. 282: 68‑81, 1986.

 

104.            Lin, C.‑I, H. Kotake and M. Vassalle. On the mechanism underlying the oscillatory current in cardiac Purkinje fibers. J. Cardiovasc. Pharmacol. 8: 906‑914, 1986.

 

105.            Kotake, H. and M. Vassalle. Rate‑force relationship and calcium overload in canine Purkinje fibers. J. Mol. Cell. Cardiol. 18: 1047‑1066, 1986.

 

106.            Abete, P. and M. Vassalle. Strophanthidin and force regulation by intracellular sodium activity in cardiac Purkinje fibers. Europ. J. Pharmacol. 141: 51‑65, 1987.

 

107.            Hasegawa, J., H. Satoh and M. Vassalle. Induction of the oscillatory current by low concentrations of caffeine in sheep cardiac Purkinje fibres. Naunyn‑Schmiedeberg's Arch. Pharmacol. 335: 310‑320, 1987.

 

108.            Di Gennaro, M., P.U. Carbonin, G. Iacono and M. Vassalle. Caffeine actions on the electro‑mechanical activity of sinus node cells. Proc. 8th Internat. Congress "The New Frontiers of Arrhythmias". 4: 99‑102, 1988.

 

109.            Apfel, H. and M. Vassalle. Acetylcholine induces overdrive excitation in sheep Purkinje fibres. Cardiovasc. Res. 22: 425‑438, 1988.

 

110.            Vassalle, M., P. Carbonin, G. Iacono and M. Di Gennaro. Induction of overdrive excitation in the sinoatrial node in the presence of caffeine. Cardiology. 75: 206‑213, 1988.

 

111.            Abete, P., R. Bernabei, M. Di Gennaro, G. Iacono, F. Rengo, P. Carbonin and M. Vassalle. Electrical and ionic mechanisms of early reperfusion arrhythmias in sheep cardiac Purkinje fibers. J. Electrocardiol. 21: 199‑212, 1988.

 

112.            Abete, P. and M. Vassalle. Relation among Na+‑K+ pump, Na+ activity and force in strophanthidin inotropy in sheep cardiac Purkinje fibres. J. Physiol. (London), 404: 275‑299, 1988.

 

113.            Liu, B., F. Golyan, J.R. McCullough and M. Vassalle. Electrophysiological and antiarrhythmic effects of the K‑channel opener, BRL 34915, in cardiac Purkinje fibers. Drug Develop. Res., 14: 123‑139, 1988.

 

114.            Hou, Z.‑Y., C.-I Lin, M. Vassalle, B.N. Chiang and K.‑K. Cheng. Role of acetylcholine in induction of repetitive activity in human atrial fibers. Am. J. Physiol. 256: H74‑H84, 1989.

 

115.            Satoh, H., J. Hasegawa and M. Vassalle. On the characteristics of the inward tail current induced by calcium overload. J. Mol. Cell. Cardiology 21: 5-20, 1989.

 

116.            Iacono, G. and M. Vassalle. Acetylcholine increases intracellular sodium activity in sheep cardiac Purkinje fibers. Am. J. Physiol. 256: H1407-H1416, 1989.

 

117.            Valenzuela, F. and M. Vassalle. On the mechanism of barium induced diastolic depolarization in isolated ventricular myocytes. Cardiovasc. Res. 23: 390-399, 1989.

 

118.            Satoh, H. and M. Vassalle. Role of calcium in caffeine-norepinephrine interactions in cardiac Purkinje fibers. Am. J. Physiol. 257:H226-H237, 1989.

 

119.            Gonzalez, M. and M. Vassalle. Electrical and mechanical effects of strontium in sheep cardiac Purkinje fibres. Cardiovasc. Res. 23:867-881, 1989.

 

120.            Yang, L. and M. Vassalle. Quinacrine decreases the slow inward current and force in guinea pig ventricular tissue. Eur. J. Pharmacol. 170: 261-263, 1989.

 

121.            Greenberg, Y.J. and M. Vassalle. On the mechanism of overdrive suppression in the guinea pig sino-atrial node. J. Electrocardiol. 23: 53-67, 1990.

 

122.            Liu, B., J.R. McCullough and M. Vassalle. On the mechanism of increased potassium conductance by the potassium channel opener BRL 34915 in isolated ventricular myocytes. Drug Develop. Res. 19: 409-423, 1990.

 

123.            Gonzalez, M. and M. Vassalle. Strontium induces oscillatory potentials in sheep cardiac Purkinje fibers. International J. Cardiol. 27: 87-99, 1990.

 

124.            Iacono, G. and M. Vassalle. On the mechanism of the different sensitivity of Purkinje and myocardial fibers to strophanthidin. J. Pharmacol. Exp. Ther. 253: 1-12, 1990.

 

125.            Yang, L. and M. Vassalle. Effects of strophanthidin on the slow inward current in guinea pig isolated ventricular myocytes. Clin. Exper. Pharmacol. Physiol. 17: 105-120, 1990.

 

126.            Greenberg, Y.J. and M. Vassalle. Calcium overload and overdrive excitation in the guinea pig sinus node. New Trends Arrhythm. 6: 1209-1222, 1990.

 

127.            Iacono, G. and M. Vassalle. The relation between cesium, intracellular sodium activity and pacemaker potential in cardiac Purkinje fibers. Can. J. Physiol. Pharmacol. 68: 1236-1246, 1990.

 

128.            Aceto, E. and M. Vassalle. Magnesium and intracellular sodium activity in cardiac Purkinje fibers. Magnesium Trace Elem. 9: 152-162, 1990.

 

129.            Abete, P., N. Ferrara, F. Rengo and M. Vassalle. Mechanisms of lidocaine actions on normal and abnormal rhythms in canine cardiac tissues in vivo and in vitro. Clin. Exper. Pharmacol. Physiol. 18: 179-191, 1991.

 

130.            Yang, L. and M. Vassalle. Acetylcholine, Ca++ overload and oscillatory potentials in isolated ventricular myocytes. Cardiology 79: 20-30, 1991.

 

131.            Vassalle, M. and J. Tamargo. An analysis of calcium effects on diastolic depolarization in sheep Purkinje fibers. J. Physiol. (Paris), 85: 27-37, 1991.

 

132.            Yang, L. and M. Vassalle. Norepinephrine induces overdrive excitation in isolated ventricular myocytes. New Trends Arrhythm. 7: 9-19, 1991.

 

133.            Valenzuela, F. and M. Vassalle. Role of the membrane potential on Ba++-induced automaticity in guinea pig cardiac myocytes. Cardiovasc. Res. 25: 421-430, 1991.

 

134.            Tamargo, J. and M. Vassalle. Mechanisms by which calcium modulates diastolic depolarization in sheep Purkinje fibers. J. Electrocardiol. 24: 349-361, 1991.

 

135.            Aceto, E. and M. Vassalle. On the mechanism of the positive inotropy of low concentrations of strophanthidin. J. Pharmcol. Exp. Ther. 259: 182-189, 1991.

 

136.            Liu, Q.-Y. and M. Vassalle. On the mechanism by which doxorubicin abolishes the oscillatory events induced by Ca-overload in single cardiac myocytes. J. Cardiovasc. Pharmacol. 18: 711-720, 1991.

 

137.            Vassalle, M., M.D. Gonzalez and S.L. Lipsius. The role of calcium in digitalis toxicity of the sino-atrial node. New Trends Arrhythm. 7: 951-956, 1991.

 

138.            Aceto, E. and M. Vassalle. On the antiarrhythmic mechanisms of magnesium in cardiac Purkinje fibers. Magnesium Trace Elem. 10: 355-363, 1991-92.

 

139.            Abete, P. and M. Vassalle. Role of intracellular Na+ activity in the negative inotropy of strophanthidin in cardiac Purkinje fibers. Eur. J. Pharmacol. 211: 399-409, 1992.

 

140.            Vassalle, M., H. Kotake and C.-I Lin. Pacemaker current, membrane resistance and K+ in cardiac Purkinje fibres. Cardiovasc. Res. 26: 383-391, 1992.

 

141.            Yeh, T.-C., M. Vassalle and C.-I Lin. Arrhythmogenic mechanisms in human atrial and ventricular muscle fibers. Cardiology 80: 205-214, 1992.

 

142.            Song, Y. and M. Vassalle. On the mechanism of depolarization-induced pacemaker potential in isolated guinea pig ventricular myocytes. New Trends Arrhyth. 8: 593-603, 1992.

 

143.            Gonzalez, M.D. and M. Vassalle. Role of oscillatory potential and pacemaker shifts in digitalis intoxication of the sino-atrial node. Circulation, 87: 1705-1714, 1993.

 

144.            Abete, P. and M. Vassalle. Role of intracellular sodium activity in the control of contraction in cardiac Purkinje fibers. J. Biomed. Sci. 1: 28-42, 1994.

 

145.            Liu, Q.-Y. and M. Vassalle. Mechanisms underlying the modulation of arrhythmogenic events by components of ischemia in guinea pig cardiac myocytes. Can. J. Physiol. Pharmacol. 72, 382-393, 1994.

 

146.            Vassalle, M. and F. Valenzuela. Role of inward K rectifier in the repetitive activity at depolarized level in single ventricular myocytes. J. Biomed. Sci. 1: 179-192, 1994.

 

147.            Iacono, G. and M. Vassalle. Effects of caffeine on intracellular sodium activity in cardiac Purkinje fibres: relation to force. Brit. J. Pharmacol. 113: 289-295, 1994.

 

148.            Shen, J.-B. and M. Vassalle. Cesium abolishes the barium-induced pacemaker potential and current in guinea pig ventricular myocytes. J. Cardiovasc. Electrophysiol. 5: 1031-1044, 1994.

 

149.            Sohn, H.G. and M. Vassalle. Cesium effects on dual pacemaker mechanisms in guinea pig sinoatrial node. J. Mol. Cell. Cardiol. 27: 563-577, 1995.

 

150.            Sternlicht, J.P. and M. Vassalle. Cesium, Na+-K+ pump and pacemaker potential in cardiac Purkinje fibers. J. Biomed. Sci. 2: 366-378, 1995.

 

151.            Spiegler, P. and M. Vassalle. Role of voltage oscillations in the automaticity of sheep cardiac Purkinje fibers. Can. J. Physiol. Pharmacol. 73: 1165-1180, 1995.

 

152.            Vassalle, M., H. Yu  and I.S. Cohen. The pacemaker current in cardiac Purkinje myocytes. J. Gen. Physiol. 106: 559-578, 1995.

 

153.            Satoh, H. and M. Vassalle. Ca2+-dependence of caffeine modulation of the rate-force relation in canine cardiac Purkinje fibers. J. Pharmacol. Exp. Ther. 278: 826-835, 1996.

 

154.            Shen, J.-B. and M. Vassalle. Barium-induced diastolic depolarization and controlling mechanisms in guinea pig ventricular muscle. J. Cardiovasc. Pharmacol. 28: 385-396, 1996.

 

155.            Song, Y., Q.-Y. Liu and M. Vassalle. On the antiarrhythmic actions of magnesium in single guinea pig ventricular myocytes. Clin. Exp. Pharmacol. Physiol. 23:830-838, 1996.

 

156.            Kim, E.M., Y. Choy and M Vassalle. Mechanisms of suppression and initiation of pacemaker activity in guinea pig sino-atrial node superfused in high [K+]o. J. Mol. Cell. Cardiol. 29:1433-1445, 1997.

 

157.            Choy, Y., E.M. Kim and M. Vassalle. Overdrive excitation in the guinea pig sino-atrial node superfused in high [K+]o. J. Biomed. Sci. 4:179-191, 1997.

 

158.            Aceto, E. and M. Vassalle. Arrhythmogenic actions of norepinephrine and acetylcholine in sheep cardiac Purkinje fibers. G. Ital. Cardiol. 28, Suppl 1: 102-109, 1998.

 

159.            Liu Y.M., H. Yu, C-Z. Li, I.S. Cohen and M. Vassalle. Cs+ effects on if and iK in rabbit sinoatrial node myocytes: implications for SA node automaticity. J. Cardiovasc. Pharmacol., 32: 783-790, 1998.

 

160.            Shen, J.-B. and M. Vassalle. On the mechanism of cesium-induced voltage and current tails in single ventricular myocytes. J. Biomed. Sci. 6: 161-175, 1999.

 

161.            Liu Q.-Y. and M. Vassalle. Role of Na-Ca exchange in the action potential changes caused by drive in cardiac myocytes exposed to different Ca2+ loads. Can. J. Physiol. Pharmacol. 77: 383-397, 1999.

 

162.            Song, J. and M. Vassalle Arrhythmogenic mechanisms of norepinephrine in depolarized single ventricular myocytes. G. It. Cardiol., 29 (Suppl. 5): 81-85, 1999.

 

163.            Zhang, H. and M. Vassalle. Role of dual pacemaker mechanisms in sino-atrial node discharge. J. Biomed. Sci. 7: 100-113, 2000.

 

164.            Berg, D.E. and M. Vassalle. Oscillatory zones and their role in normal and abnormal sheep Purkinje fiber automaticity. J. Biomed. Sci. 7: 364-379, 2000.

 

165.            Vassalle, M. and H. Zhang. On the mechanisms of cholinergic control of the sino-atrial node discharge. J. Cardiovasc. Pharmacol., 37: 173-186, 2001.

 

166.            Zhang, H. and M. Vassalle. Role of IK and If in the pacemaker mechanisms of sino-atrial node myocytes. Canadian J. Physiol. Pharmacol. 79: 963-976, 2001.

 

167.            Aceto, E. and M. Vassalle. On the role of sarcoplasmic reticulum in reperfusion arrhythmias.  G. It. Aritmol. Cardiostim.5 (Suppl. 1):166-170, 2002.

 

168.            Choi, W. S. and M. Vassalle. Mechanisms by which discharge modulates diastolic depolarization in sheep and dog Purkinje fibers. J. Electrocardiol. 35: 253-272, 2002.

 

169.            Zhang, H. and M. Vassalle On the mechanisms of adrenergic control of the sino-atrial node discharge. J. Biomed. Sci. 10: 179-192, 2003.

 

170.            Rota, M. and M. Vassalle. Patch-clamp analysis in canine cardiac Purkinje cells of a novel sodium component in the pacemaker range. J. Physiol. (London) 548.1: 147-165, 2003.

 

171.         Nett, M. P. and M. Vassalle Obligatory role of diastolic voltage oscillations in sino-atrial node discharge. J. Mol. Cell. Cardiol. 35:1257-1276, 2003.

 

172. Catanzaro, J.N., M.P Nett, M. Rota and M. Vassalle On the mechanisms underlying diastolic voltage oscillations in the sino-atrial node. J. Electrocardiol. 39: 342.e1-342-e14, 2006 [doi:10.1016/ j.jelectrocard.2006.03.006].

 

 173. Graziani A.T. and M. Vassalle M.D. Mechanisms underlying overdrive suppression and overdrive excitation in guinea pig sino-atrial node. J. Biom. Sci. ONLINE [doi: 10.1007/s11373-006-9089-3]. In press, 2006.

 

ABTRACTS

1. Baschieri, L., R.D. Ricci, G.F. Mazzuoli, P. Lotti and M. Vassalle. Studi sulla portata epatica. Atti 17 Congress. Soc. Ital. Cardiol. 1955.

2. Lotti, P. and M. Vassalle. Effetti della inalazione di ossigeno sulla emodinamica. Atti 17 Congres. Soc. Ital. Cardiol. 1955.

3. Vassalle, M., D. Biancalana and P. Lotti. II balistocardiogramma normale dell'adolescente. Atti 18 Congres. Soc. Ital. Cardiol. p. 340, 1956.

4. Lotti, P. and M. Vassalle. Modificazioni circolatorie indotte dallo pneumoperitoneo in ammalati di tubercolosi polmonare cavitaria. Atti 18 Congres. Soc. Ital. Cardiol. p. 439, 1956.

5. Lotti, P., M. Vassalle and P. Di Leo. Modificazione del balistocardiogramma patologico dopo inalazione di ossigeno. Boll. Soc. Ital. Cardiol. 1: 210, 1956.

6. Vassalle, M. and P. Lotti. Modificazioni emodinamiche indotte dall'ipnosi negli ipermetabolismi. Boll. Soc. Ital. Cardiol. 1: 226, 1956.

7. Vassalle, M. and K. Greenspan. Concealed ventricular automaticity during ouabain administration. Circulation 24: 1061, 1961.

8. Vassalle, M., K. Greenspan and B.F. Hoffman. Potassium effects during ouabain toxicity. Physiologist 4, No. 3, August, page. 1961.

9. Vassalle, M., B.F. Hoffman and J.G.H. Karis. Toxic effects of ouabain on Purkinje fibers and ventricular muscle. Bull. N. Y. Acad. Med., Second Series. 37: 871, 1961.

10. Vassalle, M., J. Karis and B. F. Hoffman. Toxic effects of ouabain on Purkinje fibers and ventricular muscle. Federation Proc. 20, No. 1, Part 1, March, 1961.

11. Greenspan, K., M. Vassalle and B.F. Hoffman. Ouabain toxicity in complete heart block. Federation Proc. 2:134, 1962.

12. Vassalle, M., K. Greenspan and B.F. Hoffman. Potassium effects on cardiac conduction and automaticity. Federation Proc. 21:134, 1962.

13. Vagnini, F.J., M. Vassalle, A. Gourin and J.H. Stuckey. The initiation of idioventricular automaticity. Bull. N. Y. Acad. Med. 42: 1041, 1966.

14. Vassalle, M., , M.J. Levine and J.H. Stuckey. The sympathetic control of idioventricular automaticity. Proc. Intern. Union Physiol. Sciences 7: 449, 1968.

15. Vassalle, M. Factors affecting ventricular pacemaker automaticity. Federation Proc. 27, 2, 1968.

16. Copen, D.L., D.P. Cirillo and M. Vassalle. On the nature of the tachycardia which follows vagal stimulation. Bull. N. Y. Acad. Med. 45: 95, 1969.

17. Krellenstein, D.J., M.B. Pliam, M. Vassalle and C. McC. Brooks. Overdrive suppression of idioventricular pacemakers in isolated canine hearts. Physiologist 12: 276,1969.

18. Mandel, W.J., M.S. Holder and M. Vassalle. Catecholamine stores under vagal control. J. Electrocardiol. 2: 216, 1969.

19. Polimeni, P.I. and M. Vassalle. Potassium fluxes in Purkinje and ventricular muscle fibers. Federation Proc. 28: 461, 1969.

20. Vassalle, M. and O, Barnabei. Norepinephrine and potassium fluxes in cardiac Purkinje fibers. Physiologist 12: 381, 1969.

21. Borasio, P.G. and M. Vassalle. Effects of norepinephrine on active transport and automaticity of cardiac Purkinje fibers. Physiologist 13: No. 3, August, .

22. Greineder, J., J.H. Stuckey and M. Vassalle. Sinus node, potassium and sympathetic system. Am. J. Cardiol. 26: 636, .

23. Borasio, P.G. and M. Vassalle. A comparison of the actions of norepinephrine and cyclic AMP on active potassium transport. Proc. Intern. Union Physiol. Sciences 9: 74, 1971.

24. Borasio, P.G. and M. Vassalle. Actions of cyclic AMP on K transport and automaticity in cardiac Purkinje fibers. Federation Proc. 30: 667, 1971.

25. Carpentier, R. and M. Vassalle. Effects of norepinephrine on the coupling ratio of the ionic pump in Purkinje fibers. Physiologist 14: 119, 1971.

26. Posner, P. and M. Vassalle. Excitatory and inhibitory actions of norepinephrine on potassium transport in cardiac Purkinje fibers. Proc. Intern. Union Physiol. Sciences 9: 458, 1971.

27. Vassalle, M. and R.G. Carpentier. Interactions among norepinephrine, potassium conductance and electrogenic sodium pump. Proc. Intern. Union Physiol. Sciences 9: 582, 1971.

28. Carpentier, R. and M. Vassalle. Hyperpolarization by electrical drive at low temperatures: an analysis of the mechanism involved. Proc. of the Fifth International Congress on Pharmacology, San Francisco, July 1972.

29. Pliam, M. B., D.J. Krellenstein, M. Vassalle and C. McC. Brooks. Sympathetic system and suppression of ventricular automaticity by fast-driving rates. J.A.M.A. 208: 1473, 1969.

30. Krellenstein, D.J., M.B. Pliam, M. Vassalle and C. McC. Brooks. Overdrive suppression of idioventricular pacemakers in isolated canine hearts. Circulation 40: 126, 1969.

31. Krellenstein, D.J. and M. Vassalle. On the mechanisms of overdrive suppression of ventricular pacemakers. Am. J. Cardiol. 23: 122, 1969.

32. Vassalle, M. Action of norepinephrine on ion transport and glycogen metabolism in cardiac Purkinje fibers. Proc. of the Fifth Annual Meeting of the International Study Group for Research in Cardiac Metabolism, Winnipeg, p. 58, June 1972.

33. Vassalle, M., R. Carpentier and P.C. Chan. The effects of norepinephrine and cyclic AMP on (Na+- K+)-activated ATPase. Physiologist 15: 293, 1972.

34. Musso, E. and M. Vassalle. Effect of endogenously-released acetylcholine on K uptake of the sinus node. Physiologist 16: 404, 1973.

35. Musso, E. and M. Vassalle. Factors affecting the release of endogenous acetylcholine in the sinus node. Circulation 48, suppl. IV-61, 1973.

36. Lipsius, S. and M. Vassalle. An analysis of the factors which may influence the effect of acetylcholine on K transport in the sinus node. Physiologist 16: 378, 1973.

37. Vassalle, M. and E. Musso. Cardiac Purkinje fibers, automaticity and digitalis. Federation Proc. 33: 432, 1974.

38. Vassalle, M. and E. Musso. Digitalis affects Purkinje fiber automaticity by different mechanisms. Bull. N.Y. Acad. Med. 51: 329, 1975.

39. Vassalle, M. Toxic mechanisms of strophanthidin in cardiac Purkinje fibers. Physiologist 18: 429, 1975.

40. Musso, E. and M. Vassalle. Interactions of norepinephrine, calcium and rate of discharge on K-exchange in cardiac Purkinje fibers. Federation Proc. 34: 434, 1975.

41. Vassalle, M., M. Cummins, C. Castro and J.H. Stuckey. Overdrive suppression and overdrive excitation of ventricular pacemakers. Federation Proc. 35: 221, 1976.

42. Loeb, J.M. and M. Vassalle. The positive chronotropic action of the vagus nerve on the heart. Federation Proc. 35: 446, 1976.

43. Lipsius, S.L. and M. Vassalle. Effects of ionic changes and glycosides on sinus node action potentials. Federation Proc. 35: 319, 1976.

44. Lipsius, S.L. and M. Vassalle. Action of tetrodotoxin on the upstroke of the sinus node action potential. Physiologist 19: 273, 1976.

45. Lin, C.-I and M. Vassalle. Role of sodium in strophanthidin toxicity in cardiac Purkinje fibers. Physiologist 19: 271, 176.

46. Musso, E. and M. Vassalle. Interazione fra orepinefrina, Ca++ e frequenza di stimolazione sul comportamento dei flussi potassici nelle fibre di Purkinje. Boll. Soc. Italiana Cardiologia 21: 1523-1524, 1976.

47. Vassalle, M. and C.-I Lin. Calcium and strophanthidin toxicity. Federation Proc. 36: 435, 1977.

48. Vassalle, M., R. Knob, M. Cummins, G. Lara, C. Castro and J.H. Stuckey. A characterization of the fast idioventricular rhythm. Proc. XXVIIth Internat. Congress Physiol. Sci. Paris, 1977.

49. Lipsius, S.L. and M. Vassalle. Interaction of digoxin and calcium on sinus node activity. Bull. N.Y. Acad. Med. 53: 316, 1977.

50. Lin, C.-I and M. Vassalle. Rubidium effects in the presence and absence of strophanthidin in cardiac Purkinje fibers. Bull. N.Y. Acad. Med. 54: 322, 1978.

51. Bhattacharyya, M.L. and M. Vassalle. Interactions between norepinephrine and strophanthidin in cardiac Purkinje fibers. Bull. N.Y. Acad. Med. 54: 311, 1978.

52. Bhattacharyya, M.L. and M. Vassalle. Effects of strophanthidin in the presence and absence of tetrodotoxin. Federation Proc. 37: 656, 1978.

54. Bhattacharyya, M.L. and M. Vassalle. Factors conditioning the positive inotropic action of strophanthidin in cardiac Purkinje fibers. Bull. N.Y. Acad. Med. 55: 407, 1979.

55. Vassalle, M. and E. Musso. The role of calcium in overdrive suppression of cardiac Purkinje fibers. Proc. 7th Internat. Congr. Pharmacol., p. 42, Paris 1978.

56. Vassalle, M. Cardiac arrhythmias induced by cardiac glycosides. Proc. 7th Internat. Congr. Pharmacol., Paris 1978, p. 316. Symposium on New Developments in Antiarrhythmic drugs.

57. Valenzuela, F. and M. Vassalle. Overdrive excitation in isolated canine conducting tissue. Physiologist 21: 123, 1978.

58. Vassalle, M., A. Mugelli and W.R. Gibbons. Oscillatory current and pacemaker activity. Physiologist 21: 124, 1978.

59. Bhattacharyya, M.L. and M. Vassalle. Strophanthidin toxicity and local anesthetics. Federation Proc. 38: 880, 1979.

60. Lin, C.-I and M. Vassalle. Calcium overload and mechanical toxicity induced by strophanthidin. Federation Proc. 38: 1441, 1979.

61. Vassalle, M. and E.E. Scidá. The role of sodium in spontaneous discharge in the absence and in the presence of strophanthidin. Federation Proc. 38: 880, 1979.

62. Vassalle, M. and M. Bhattacharyya. Local anesthetics and the role of sodium in the force development of ventricular muscles and Purkinje fibers. Federation Proc. 39: 3, 1980.

63. Vassalle, M. and M. Bhattacharyya. Positive and negative inotropic effects of local anesthetics in cardiac fibers. Proc. Internat. Union Physiol. Sci. 14: 768, 1980.

64. Vassalle, M. and S. Ishikawa. The effects of strophanthidin on diastolic depolarization. Physiologist 23: 160, 1980.

65. Li, T. and M. Vassalle. Inotropic effects of cardiac glycosides on cardiac muscle at different Na, Ca concentrations. Physiologist 23: 161, 1980.

66. Ishikawa, S. and M. Vassalle. The action of different substrates on the mechanical toxicity of strophanthidin. Federation Proc. 40: 662, 1981.

67. Li, T. and M. Vassalle. The effect of low sodium-calcium solutions on cardiac contraction in the absence and presence of cardiac steroids. Federation Proc. 40: 392, 1981.

68. Bhattacharyya, M.L. and M. Vassalle. The relationship between strophanthidin induced arrhythmias and contracture in cardiac Purkinje fibers. Federation Proc. 40: 674, 1981.

69. Mehta, N.L. and M. Vassalle. The dependence of strophanthidin inotropy on sodium concentration and calcium overload. Circulation 64: IV-273, 1981.

70. Vassalle, M. Electrophysiological basis of normal and abnormal automaticity. New Frontiers in Arrhythmias, Proc. Internat. Congr., 10-11, 1982.

71. Di Gennaro, M., P.U. Carbonin and M. Vassalle. The interaction between digitalis and caffeine in guinea pig ventricular muscle. Federation Proc. 41: 1107, 1982.

72. Vassalle, M. and M. Di Gennaro. Effects of caffeine on electrical and mechanical events in cardiac tissues. Federation Proc. 41: 1983, 1982.

73. Bernabei, R. and M. Vassalle. Strophanthidin, sodium pump and contractile force. Physiologist 25: 197, 1982.

74. Kotake, H. and M. Vassalle. Frequency, contractile force and calcium load. Physiologist 25: 285, 1982.

75. Vassalle, M., H. Kotake and C.-I Lin. Changes in membrane resistance during the pacemaker current in Purkinje fibers. Physiologist 26: A-90, 1983.

76. Lin, C.I, Kotake, H. and M. Vassalle. On the mechanism underlying the oscillatory current in cardiac Purkinje fibers. Physiologist 26: A-90, 1983.

77. Kotake, H., C.-I Lin and M. Vassalle. On the mechanism of action of low Na solution on the pacemaker current. Physiologist 26: A-90, 1983.

78. Paspa, P. and M. Vassalle. The induction of oscillatory potentials by caffeine in cardiac tissue. Federation Proc. 42: 730, 1983.

79. Vassalle, M. Electrophysiological basis of cardiac arrhythmias. Vlll Asian-Pacific Congress of Cardiology. p. 36, A-131, 1983.

80. Lin, C.-I, H. Kotake and M. Vassalle. Further characterization of the oscillatory current in ventricular Purkinje fibers. VIII Asian-Pacific Congress of Cardiology. p. 169, A-624, 1983.

81. Satoh, H. and M. Vassalle. Reversal of caffeine-induced calcium overload. Federation Proc. 43: 1493, 1984.

82. Vassalle, M. and M. Di Gennaro. Caffeine actions on currents induced by calciumoverload in Purkinje fibers. Federation Proc. 43: 2055, 1984.

83. Vassalle, M., R. Bernabei, P.U. Carbonin and L. Tung. The inotropic action of strophanthidin at different sodium and calcium concentrations. Physiologist 27: 233, 1984.

84. , J., H. Satoh and M. Vassalle. Effects of a low concentration of caffeine on the oscillatory current. Federation Proc. 44: 806, 1985.

85. Satoh, H., J. and M. Vassalle. On the characteristics of the inward current induced by calcium overload. Federation Proc. 44: 806, 1985.

86. Abete, P., C.O. Lee, M. Pecker, J.K. Sonn and M. Vassalle. Strophanthidin inotropy: role of intracellular Na ion activity and Na-Ca exchange. Federation Proc. 44: 1579, 1985.

87. Abete, P. and M. Vassalle. A role of calcium in strophanthidin inotropy. Physiologist 28: 364, 1985.

88. Abete, P. and M. Vassalle. Intracellular sodium activity and strophanthidin inotropy under conditions that vary cellular sodium. Circulation. 72: 379, 1985.

89. Di Gennaro, M., M. Vassalle, G. Iacono, M. Pahor, R. Bernabei and P. Carbonin. On the mechanism by which hypoxia abolishes the arrhythmias induced by cardiac steroids. Physiologist 28: 364, 1985.

90. , J. and M. Vassalle. Effect of caffeine on the slow inward current in sheep cardiac Purkinje fibers. Federation Proc. 45: 288, 1986.

91. Abete, P., R. Bernabei, M. Di Gennaro, G. lacono, F. Rengo, P.U. Carbonin and M. Vassalle. On the ionic mechanisms of reperfusion arrhythmias. Federation Proc. 45: 288, 1986.

92. Lin, C.-I, Z.Y. Hou, B.N. Chiang, K.-K. Cheng and M. Vassalle. Acetylcholine induced suppression and initiation of spontaneous activity in human atrial fibers. J. Mol. Cell. Cardiol. 18: 45, 1986.

93. Abete, P. and M. Vassalle. Strophanthidin inotropy, overdrive and intracellular sodium activity. Proc. Intern. Union Physiol. Sci. 16: 351, 1986.

94. Iacono, G. and M. Vassalle. Acetylcholine increases intracellular sodium activity in sheep Purkinje fibers. Circulation 74: 11-256, 1986.

95. Apfel, H. and M. Vassalle. Acetycholine induces overdrive excitation in cardiac sheep Purkinje fibers. Federation Proc. 46: 336, 1987.

96. Abete, P., N. Ferrara, F. Rengo and M. Vassalle. Mechanisms of different actions of lidocaine on different pacemaker rhythms studied in vivo and in vitro. Federation Proc. 46: 336, 1987.

97. Tamargo, J. and M. Vassalle. Effects of calcium on diastolic depolarization of cardiac Purkinje fibers. Federation Proc. 46: 3336, 1987.

98. Di Gennaro, M., P. Carbonin, G. Iacono, and M. Vassalle. Actions of caffeine on the sino-atriall node. Federation Proc. 46: 336, 1987.

99. Liu, B., D. Golyan, J.R. McCullough and M. Vassalle. Electrophysiological and antiarrhythmic effects of the K Channel opener BRL 34915 in Purkinje fibers. Physiologist 30: 178, 1987.

100. Vassalle, M. and G. Iacono. Cesium, intracellular sodium activity and diastolic depolarization in Purkinje fibers. FASEB J. 2: A1278, 1988.

101. Iacono, G. and M. Vassalle. Caffeine increases intracellular sodium activity in sheep Purkinje fiberss. FASEB J. 2: A1278, 1988.

102. Valenzuela, F., M. Vassalle and A. Sastillan. Analisis del mechanismo ionico responsable del automatismo inducido por bario en miocitos ventriculares aislados. Arch. Inst. Cardiol. Mex. 57: 510, 1987.

103. Satoh, H. and M. Vassalle. Caffeine-norepinephrine interactions in cardiac Purkinje fibers. Physiologist 31: A37, 1988.

104. Gonzalez, M. and M. Vassalle. Electrical and mechanical effects of strontium in sheep cardiac Purkinje fibers. Physiologist 31: A131, 1988.

105. Yang, L. and M. Vassalle. The actions of strophanthidin on the slow inward current and force in guinea pig myocardial cells. FASEB J. 3: A847, 1989.

106. Aceto, E. and M. Vassalle. Actions of magnesium on intracellular sodium activity in the absence and presence of strophanthidin. FASEB J. 3: A847, 1989.

107. Greenberg, Y.J. and M. Vassalle. The role of calcium in overdrive suppression in the guinea pig sino-atrial node. FASEB J. 3: A970, 1989.

108. Iacono, G. and M. Vassalle. On the mechanism of the different sensitivity of Purkinje fibers and myocardial fibers to strophanthidin. Physiologist 32: 185, 1989.

109. Gonzalez, M.D. and M. Vassalle. Strontium induces oscillatory potentials in sheep cardiac Purkinje fibers. Physiologist 32: 185, 1989.

110. Liu, B., J.R. McCullogh and M. Vassalle. On the mechanism of increased potassium conductance by the potassium channel opener BRL 34915 in isolated ventricular myocytes. Physiologist 32: 185, 1989.

111. Vassalle, M. and Y.J. Grenberg. Calcium overload and overdrive excitation in sinus node. Proc. Internat. Union Physiol. Sci. 17: 476, 1989.

112. Aceto, E. and M. Vassalle. Intracellular Na+ activity and the inotropic effects of low concentrations of strophanthidin. FASEB J. 4: A735, 1990.

113. Song, Y. and M. Vassalle. Depolarization-induced diastolic depolarization in isolated guinea pig myocytes. FASEB J. 4: A682, 1990.

114. Valenzuela, F. and M. Vassalle. The factors involved in barium-induced automaticity of isolated cardiac myocytes. FASEB J. 4: A682, 1990.

115. Yang, L. and M. Vassalle. The induction of overdrive excitation in isolated ventricular myopcytes. Biophys. J. 57: 137a, 1990.

116. Liu, Q.-Y. and M. Vassalle. On the mechanism by which doxorubicin abolishes the oscillatory potential. Biophys. J. 59: 558a, 1991.

117. Vassalle, M. and F. Valenzuela. On the mechanism of repetitive activity at depolarized level in cardiac myocytes. FASEB J. 5: A380, 1991.

118. Gonzalez, M. and M. Vassalle. Role of the oscillatory potential in ouabain intoxication of the sinus node. FASEB J. 5: A380, 1991.

119. Liu, Q.-Y. and M. Vassalle. Voltage and current changes induced by calcium overload during overdrive. FASEB J. 5: A380, 1991.

120. Vassalle, M., Y. Song, Q.-Y. Liu and E. Aceto. On the mechanism of the antiarrhythmmic action of magnesium. Proc. 6th Southeast Asian/Western Pacific Regional Meeting of Pharmacologist. p. 99, 1991.

121. Lu, G. and M. Vassalle. On the mechanism of the changes in action potential induced by activity. FASEB J. 6: A1163, 1992

122. Sternlicht J. and M. Vassalle. Cesium abolishes diastolic depolarization of Purkinje fibers by blocking a K+ conductance. FASEB J. 6: A1163, 1992.

123. Shen, J.-B. and M. Vassalle. Cesium abolishes Ba-induced pacemaker potential and pacemaker current in guinea pig ventricular tissue. Biophysical J. 64: A240, 1993.

124. Spiegler, P.A. and M. Vassalle. Role of membrane potential oscillations in spontaneous and induced activity in sheep Purkinje fibers. FASEB J. 7: A96, 1993.

125. Valenzuela, F. and M. Vassalle. Characterization of the current underlying the inward rectification negative slope in guinea pig myocytes. FASEB J. 7: A96, 1993.

126. Liu, Q.-Y. and M. Vassalle. Mechanisms of changes in action potential and currents induced by repetitive activity in isolated myocytes. FASEB J. 7: A96, 1993.

127. Sohn, H.G. and M. Vassalle. The pacemaker potential is not blocked by cesium in the dominant sino-atrial node cells. FASEB J. 8: A7, 1994.

128. Aceto, E. and M. Vassalle. Arrhythmogenic actions of norepinephrine and acetylcholine in sheep cardiac Purkinje fibers. FASEB J. 8: A610, 1994.

129. Song, Y., Q.-Y. Liu and M. Vassalle. Extracellular magnesium and the slow inward current in single ventricular myocytes. FASEB J. 8: A610, 1994.

130. Vassalle, M., H. Yu and I.S. Cohen. Time-dependent decay of a K+ current generates a "pacemaker" current at diastolic potentials in Purkinje myocytes. Circulation 90: I-4, 1994.

131. Vassalle, M., H. Yu, Y. Liu, C. Tromba and I.S. Cohen. Diastolic membrane currents in Purkinje and sinus node myocytes. Biophys. J. 68: A107, 1995.

132. Kim, E.M., Y. Choy and M. Vassalle. Suppression and initiation of pacemaker activity in the sino-atrial node perfused in high [K]o. Biophys. J. 68: A107, 1995.

133. Choy, Y., E.M. Kim and M. Vassalle. Overdrive excitation in the sino-atrial node in the presence of high [K]o. Biophys. J. 68: A109, 1995.

134. Vassalle, M. Role of the autonomic system in cardiac automaticity and its disturbances. It. Soc. Cardiovasc. Res., Proc. Second National Congress. 31-32, 1995.

135. Vassalle, M., H. Yu and I.S. Cohen. A study of the ionic mechanism underlying the pacemaker current in canine single Purkinje myocytes. It. Soc. Cardiovasc. Res., Proc. Second National Congress, 134-135, 1995.

136. Vassalle M. Role of the autonomic system in cardiac automaticity and its disturbances. Proc. Second Congress of the It. Soc. Cardiovasc. Res. 31-32, 1995.

137. Zhang, H. and M. Vassalle. Effects of blockers of diastolic time-dependent currents on the pacemaker potential of sino-atrial node. Biophys. J. 70: A-390, 1996.

138. Vassalle, M. and H. Zhang. Block of different diastolic currents and the sino-atrial node discharge. FASEB J. 10: A66, 1996.

139. Zhang H. and M. Vassalle. Regulation of the guinea pig sino-atrial node discharge by vagal and sympathetic mediators. FASEB J. 11: A494, 1997.

140. Liu, Y.M., H. Yu, C.Z. Li, I.S. Cohen and M.Vassalle, M. Action of Cs+ and Ba2+ on diastolic time-dependent currents in rabbit SA node myocytes. FASEB J. 11: A496, 1997.

141. Berg, D. E. and M. Vassalle. Oscillatory zones and their role in normal and abnormal sheep Purkinje fiber automaticity. FASEB J. 12: A713, 1998.

142. Du, F. and M. Vassalle. A 4-aminopyridine sensitive current activating during slow ramps in cardiac single Purkinje cells. FASEB J. 13: A97, 1999.

144. Vassalle, M. and F. Du. Relationship between inward rectification and inward transients during depolarizing ramps. FASEB J. 13: A97, 1999.

142. Zhang, H. and M. Vassalle. Currents underlying sino-atrial node discharge. FASEB J. 13: A105, 1999.

145. Choi, W.S. and M. Vassalle. Factors modulating diastolic depolarization in sheep and dog Purkinje fibers. FASEB J. 13: A105, 1999.

146. Vassalle, M and F. Du. A slow sodium current in single Purkinje cells. FASEB J. 14: A699, 2000.

147. Bocchi, L. and M. Vassalle. An analysis of the slow sodium current in single Purkinje and myocardial cells. FASEB J. 14: A699, 2000.

148. Zhang, H. and M. Vassalle. Activation and deactivation of If in SA node single cells. FASEB J. 14: A697, 2000

149. Bocchi, L. and M. Vassalle. A slow sodium current present in Purkinje but not in myocardial single cells. It. Heart J. 1(Suppl 3): S91, 2000.

150. Zhang, H. and M. Vassalle. The fast sodium current in guinea pig SA node myocytes. FASEB J. 15: A1134, 2001.

151. Nett, M. and M. Vassalle. Role of Na-Ca exchange in the discharge of sino-atrial node. FASEB J. 15: A1134, 2001.

152. Bocchi, L., E. Musso and M. Vassalle. Characterization of INa2, a slow sodium current in Purkinje single cells. Pflüglers Archiv, Europ. J. Physiol. 442: R56, 2001.

153. Rota, M. and M. Vassalle. Role of inward rectification and Na+ in cardiac Purkinje fiber discharge. Biophysical J. 82: 94a, 2002

154. Vassalle, M., M.P. Nett., J. Catanzaro and M. Rota. Mechanisms by which caffeine alters sino-atrial node discharge. Biophysical J. 82: 96a, 2002.

155. Rota, M. and M. Vassalle. Separation of INa from the INa3 component in canine cardiac Purkinje cells. FASEB J. 17: A116, 2003.

156. Graziani, A.T. and M. Vassalle. Overdrive suppression and overdrive excitation in guinea pig sino-atrial node. FASEB J. 17: A116, 2003.

157. Rota, M. and M. Vassalle Different Na+ currents in single Purkinje cells. FASEB J. 18: A227, 2004.

158. Catanzaro, J.N., M. P. Nett, M. Rota and M. Vassalle. Role of diastolic oscillations in the autonomic control of the sino-atrial node. FASEB J. 18: A227, 2004.

159. Rota, M. and M. Vassalle Fast and slow Na+ currents in canine cardiac Purkinje cells. J. Gen Physiol. 124 (1):26a-27a, 2004.

160. Catanzaro, J.N., M. P. Nett, M. Rota and M. Vassalle. Diastolic oscillations and the mechanisms of sympathetic and cholinergic control of the sino-atrial node discharge. J. Gen. Physiol. 124 (1): 27a, 2004.

161. Graziani, A.T. and M. Vassalle Relationship between overdrive suppression and overdrive excitation in the sino-atrial node. J. Gen. Physiol. 124 (1):27a-28a, 2004.

162. Vassalle, M. and M. Rota. Activation, inactivation and deactivation of the slow Na+ currents INa2 and INa3 in cardiac single Purkinje cells. Exper. Biol. 2005, Abs. 917.17.

163. Vassalle, M. Essential role of the Na+-K+ pump in the control of cardiac idioventricular automaticity. J. Gen. Physiol, 126: 43a, 2005.