Biologics Study Regulatory Actions

Frequently Asked Questions

All letters issued by FDA's Center for Biologics Evaluation and Research during 2005 involved medical devices, [except Hostoffer, which was a drug] and are flagged as "CBER Warning Letter" in the device case list.

Dr. Lein     10-12-2006 Warning Letter
In view of the falsifications, I am surprised that only a Warning Letter was issued.

Dr. Hohmann     7-10-2006 Warning Letter
After she had dosed the last subject with the investigational vaccine, she sought FDA guidance concerning the need for an IND. An FDA representative told her that she needed an IND to conduct the study. Nevertheless, she failed to submit an IND to FDA, and continued to follow the subjects through August 2004 when she informed the IRB that the study was closed.


Envita Natural Medical Centers of America     6-14-2006 Warning Letter
Biological products and drug products may be distributed for clinical use in humans only if the sponsor has an investigational new drug (IND) application in effect Your treated cell cultures are not the subject of an approved BLA or NDA, and you do not have an IND in effect.